研究業績

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2012年研究業績

英文総説

  1. Toubai T, Tanaka J, Paczesny S, Shono Y, Reddy P, Imamura M.: Role of cytokines in the pathophysiology of acute graft-versus-host disease (GVHD): are serum/plasma cytokines potential biomarkers for diagnosis of acute GVHD following allogeneic hematopoietic cell transplantation (Allo-HCT)? Curr Stem Cell  Res Ther. 2012 May; 7(3): 229-239
  2. Teshima T: GVHD-associated immunosuppression: soil or seed? Blood 119(24); 5618-5619, 2012. (commentary)

英文原著

  1. Kanda J, Ichinohe T, Kato S, Uchida N, Terakura S, Fukuda T, Hidaka M, Ueda Y, Kondo T, Taniguchi S, Takahashi S, Nagamura-Inoue T, Tanaka J, Atsuta Y, Miyamura K, Kanda Y.: Unrelated cord blood transplantation vs. related transplantation with HLA 1-antigen mismatch in the graft-versus-host direction. Leukemia (in press)
  2. Tsutsumi Y, Ogasawara R, Miyashita N, Tanaka J, Asaka M, Imamura M.: HBV reactivation in malignant lymphoma patients treated with rituximab and bendamustine. Int J Hematol. 2012; 95(5): 588-591
  3. Tsutsumi Y, Ogasawara R, Ito S, Sasaki J, Morita A, Senoo N, Murata N, Tanaka J, Asaka M, Imamura M.: Retrospective analysis of an efficient peripheral blood stem cell collection and the relation between infused cell dose and clinical outcome in patients with malignant lymphoma and multiple myeloma. Int J Lab Hematol. 2012; 34(4): 403-409
  4. Kanda J, Saji H, Fukuda T, Kobayashi T, Miyamura K, Eto T, Kurokawa M, Kanamori H, Mori T, Hidaka M, Iwato K, Yoshida T, Sakamaki H, Tanaka J, Kawa K, Morishima Y, Suzuki R, Atsuta Y, Kanda Y.: Related transplantation with HLA 1-antigen mismatch in the graft-versus-host direction and HLA 8/8-allele-matched unrelated transplantation: A nationwide retrospective study. Blood 2012; 119(10): 2409-2416
  5. Imahashi N, Suzuki R, Fukuda T, Kakihana K, Kanamori H, Eto T, Mori T, Kobayashi N, Iwato K, Sakura T, Ikegame K, Kurokawa M, Kondo T, Iida H, Sakamaki H, Tanaka J, Kawa K, Morishima Y, Atsuta Y, Miyamura K.: Allogeneic hematopoietic stem cell transplantation for intermediate cytogenetic risk acute myeloid leukemia in first complete remission. Bone Marrow Transplant in press
  6. Tanaka J, Sugita J, Shiratori S, Shigematsu A, Imamura M.: Dasatinib enhances the expansion of CD56+CD3- NK cells from cord blood. Blood in press
  7. Tanaka J, Sugita J, Shiratori S, Shigematsu A, Asanuma S, Fujimoto K, Nishio M, Kondo T, Imamura M.: Expansion of NK cells from cord blood with antileukemic activity using GMP-compliant substances without feeder cells. Leukemia 2012 May; 26(5): 1149-1152
  8. Yoshida M, Tamura K, Imamura M, Niitsu Y, Sasaki T, Urabe A, Ohyashiki K, Naoe T, Kanamaru A, Tanimoto M, Masaoka T.: Efficacy and safety of micafungin as an empirical antifungal therapy for suspected fungal infection in neutropenic patients with hematological disorders. Ann Hematol. 2012 Mar; 91(3): 449-457
  9. Sugita J, Matsushita T, Kashiwazaki H, Kosugi M, Takahashi S, Wakasa K, Shiratori S, Ibata M, Shono Y, Shigematsu A, Obara M, Fujimoto K, Endo T, Nishio M, Kondo T, Hashino S, Tanaka J, Asaka M, Imamura M.: Efficacy of folinic acid in preventing oral mucositis in allogeneic hematopoietic stem cell transplant patients receiving MTX as prophylaxis for GVHD. Bone Marrow Transplant. 2012 Feb; 47(2): 258-264
  10. Hashino S, Morita L, Kanamori H, Takahata M, Onozawa M, Nakagawa M, Kawamura T, Fujisawa F, Kahata K, Izumiyama K, Yonezumi M, Chiba K, Kondo T, Asaka M.: Clinical impact of cycling administration of antibiotics for febrile neutropenia in Japanese patients with hematological malignancy. Eur J Clin Microbiol Infect Dis. 2012 Feb; 31(2): 173-178
  11. Kashiwazaki H, Matsushita T, Sugita J, Shigematsu A, Kasashi K, Yamazaki Y, Kanehira T, Yamamoto S, Kondo T, Endo T, Tanaka J, Hashino S, Nishio M, Imamura M, Kitagawa Y and Inoue N: Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation. Support Care Cancer. 2012 Feb; 20(2): 367-373
  12. Eriguchi Y, Takashima S, Oka H, Shimoji S, Nakamura K, Uryu H, Shimoda S, Iwasaki H, Shimono N, Ayabe T, Akashi K, Teshima T.: Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of α-defensins. Blood 120(1); 223-231, 2012.
  13. Ferrara JL, Harris AC, Greenson JK, Braun TM, Holler E, Teshima T, Levine JE, Choi SW, Huber E, Landfried K, Akashi K, Vander Lugt M, Reddy P, Chin A, Zhang Q, Hanash S, Paczesny S.: Regenerating islet-derived 3 alpha is a biomarker of gastrointestinal graft-versus-host disease. Blood 118(25); 6702-6708, 2011.
  14. Harris AC, Ferrara JL, Braun TM, Holler E, Teshima T, Levine JE, Choi SW, Landfried K, Akashi K, Vander Lugt M, Couriel DR, Reddy P, Paczesny S.: Plasma biomarker of loser gastrointestinal and liver acute graft-versus-host disease. Blood 119(12); 2960-2963, 2012.
  15. Kamimura T, Miyamoto T, Kawano N, Numato A, Ito Y, Chong Y, Nagafuji K, Teshima T, Hayashi S, Akashi K.: Successful treatment by donor lymphocyte infusion of adult T-cell leukemia/lymphoma relapse following allogeneic hematopoietic stem cell transplantation. Int J Hematol 95(6); 725-30, 2012.
  16. Kim Y, Alpmann P, Blaum-Feder S, Krämer S, Endo T, Lu D, Carson D, Schmidt-Wolf IG.: Increased in vivo efficacy of lenalidomide by Addition of Piroctone Olamine. In Vivo 25; 99-103, 2012.
  17. Kuriyama T, Takenaka K, Kohno K, Yamauchi T, Daitoku S, Yoshimoto G, Kikushige Y, Kishimoto J, Abe Y, Harada N, Miyamoto T, Iwasaki H, Teshima T, Akashi K.: Engulfment of hematopoietic stem cells caused by down-regulation of CD47 is critical in the pathogenesis of hemophagocytic lymphohistiocytosis. Blood 120(19); 4058-4067, 2012.
  18. Kurosawa M, Yonezumi M, Hashino S, Tanaka J, Nishio M, Kaneda M, Ota S, Koda K, Suzuki N, Yoshida M, Hirayama Y, Takimoto R, Torimoto Y, Mori A, Takahashi T, Iizuka S, Ishida T, Kobayashi R, Oda T, Sakai H, Yamamoto S, Takahashi F, FukuharaT.: Epidemiology and treatment outcome of invasive fungal infections in patients with hematological malignancies. Int J Hematol 96(6); 748-757, 2012.
  19. Kurosawa S, Yakushijin K, Yamaguchi T, Atsuta Y, Nagamura-Inoue T, Akiyama H, Taniguchi S, Miyamura K, Takahashi S, Eto T, Ogawa H, Kurokawa M, Morishima Y, Tanaka J, Sakamaki H, Fukuda T.: Changes in incidence and causes of non-relapse mortality after allogeneic hematopoietic cell transplantation in patients with acute leukemia/myelodysplastic syndrome. Bone Marrow Transplant (in press)
  20. Mori Y, Miyamoto T, Kato K, Kamezaki K, Kuriyama T, Oku S, Takenaka K, Iwasaki H, Harada N, Shiratsuchi M, Abe Y, Nagafuji K, Teshima T, Akashi K.: Different risk factors related to adenovirus- or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation. Biol Blood Marrow Transplant 18(3); 458-465, 2012.
  21. Mori Y, Teshima T, Kamezaki K, Kato K, Takenaka K, Iwasaki H, Miyamoto T, Nagafuji K, Eto T, Akashi K.: Validation of pretransplantation assessment of mortality risk score in the outcome of hematopoietic stem cell transplantation in non-Caucasians. Bone Marrow Transplant 47; 1075-81, 2012.
  22. Mori Y, Miyamoto T, Kamezaki K, Kato K, Kikushige Y, Takashima S, Urata S, Shimoda S, Shimono N, Takenaka K, Iwasaki H, Nagafuji K, Teshima T, Akashi K.: Low incidence of adenovirus hemorrhagic cystitis following autologous hematopoietic stem cell transplantation in the rituximab era. Am J Hematol 87(8); 828-830, 2012. (Letter)
  23. Nishimori H, Maeda Y, Teshima T, Sugiyama H, Kobayashi K, Yamasuji Y, Kadohisa S, Uryu H, Takeuchi K, Tanaka T, Yoshino T, Iwakura Y, Tanimoto M.: Synthetic retinoid Am80 ameliorates chronic graft-versus-host disease by downregulating Th1 and Th17. Blood 119(1); 285-295, 2012.
  24. Nishiwaki S, Miyamura K, Ohashi K, Kurokawa M, Taniguchi S, Fukuda T, Ikegame K, Takahashi S, Mori T, Imai K, Iida H, Hidaka M, Sakamaki H, Morisima Y, Kato K, Suzuki R, Tanaka J.: Impact of donor source on adult Philadelphia chromosome-negative acute lymphoblastic leukemia: a retrospective analysis from the Adult Acute Lymphoblastic Leukemia Working Group of the Japan Society forHematopoietic Cell Transplantation. Ann Oncology (in press)
  25. Pillai SK, Abdel-Mohsen M, Guatelli J, Skasko M, Monto A, Fujimoto K, Yukl S, Greene WC, Kovari H, Rauch A, Fellay J, Battegay M, Hirschel B, Witteck A, Bernasconi E, Ledergerber B, Günthard HF, Wong JK.: Swiss HIV Cohort Study. Role of retroviral restriction factors in the interferon-α-mediated suppression of HIV-1 in vivo. Proc Natl Acad Sci USA 109; 3035-40, 2012.
  26. Shima T, Miyamoto T, Kikushige Y, Mori Y, Kamezaki K, Takase K, Henzan N, Numata A, Ito A, Takenaka K, Iwasaki H, Kamimura T, Eto T, Nagafuji K, Teshima T, Kato K, Akashi K.: Quantification of hematogones at the time of engraftment is a useful prognostic indicator in allogeneic stem cell transplantation. Blood online, 2012.
  27. Shima T, Forraz N, Sato N, Yamauchi T, Iwasaki H, Takenaka K, Akashi K, McGuckin C, Teshima T.: A novel filtration method for cord blood processing using a polyester fabric filter. Int J Lab Hematol online, 2012.
  28. Shirasugi Y, Ando K, Miyazaki K, Tomiyama Y, Iwato K, Okamoto S, Kurokawa M, Kirito K, Hashino S, Ninomiya H, Mori S, Yonemura Y, Usuki K, Wei H, Lizambri R.: An open-label extension study evaluating the safety and efficacy of romiplostim for up to 3.5 years in thrombocytopenic Japanese patients with immune thrombocytopenic purpura (ITP). Int J Hematol 95; 652-659, 2012.
  29. Takenaka K, Nagafuji K, Takase K, Kamimura T, Mori Y, Ito Y, Henzan H, Kato K, Harada N, Eto T, Miyamoto T, Teshima T, Akashi K.: Initial low-dose valganciclovir as a preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients. Int J Hematol 96(1); 94-100, 2012.
  30. Tanaka J, Sugita J, Shiratori S, Shigematsu A, Asanuma S, Fujimoto K, Nishio M, Kondo T, Imamura M.:Expansion of NK cells from cord blood with antileukemic activity using GMP-compliant substances without feeder cells. Leukemia 26(5); 1149-1152, 2012.

英文症例報告

  1. Matsukawa T, Shigematsu A, Hayasaka K, Fujisawa S, Asanuma S, Yasumoto A, Goto H, Takahata M, Endo T, Tanaka J, Hashino S, Shimizu C, Imamura M.: Chimerism analyses by sex-chromosome analysis confused relapse with donor cell leukemia after sex-mismatched allo-SCT. Bone Marrow Transplant. 2012 Apr 9
  2. Matsukawa T, Goto H, Takahashi K, Asanuma S, Yasumoto A, Takahata M, Shigematsu A, Endo T, Tanaka J, Hashino S, Tanaka S, Imamura M.: A fatal case of cytomegalovirus ventriculoencephalitis in a mycosis fungoides patient who received multiple umbilical cord blood cell transplantations. Int J Hematol. 2012 Feb; 95(2): 217-22
  3. Hoshina D, Arita K, Mizuno O, Fujimoto K, Nishio M, Kondo T, Abe R, Shimizu H.: Skin involvement in ALK-negative systemic anaplastic large-cell lymphoma. J Am Acad Dermatol 67; e159-60, 2012.
  4. Ohe M and Hashino S.: Successful treatment of eosinophilic gastroenteritis with clarithromycin. Korean J Intern Med 27; 451-454, 2012.
  5. Okada K, Higashiyama A, Takahata M, Onozawa M, Kahata K, Ando S, Tanaka J, Hashino S, Imamura M.: Complete remission following chemotherapy with low-dose cytosine arabinoside and macrophage colony-stimulating factor/granulocyte colony-stimulating factor in a patient with relapsed acute myeloid leukemia after stem cell transplantation. Intern Med 51(20);2937-41, 2012.

英文著書

  1. Ohba Y, Darmanin S, Mizutani T, Tsuda T and Kondo T: Biosensors for BCR-ABL activity and their application to cancer. Biosensors and Cancer. RJ Hunter and VR Preedy(ed.) Science Publishers London,in press

和文総説

  1. 今村雅寛:血液疾患治療の最近の動向.日本臨床内科医会会誌 26:616-620,2012
  2. 今村雅寛:同種造血幹細胞移植後のドナー細胞白血病.血液フロンティア 22: 96-99,2012
  3. 田中淳司:造血幹細胞移植におけるGVHD/GVL制御とNK細胞 41-49
    (Annual Review 血液2012、中外医学社)2012
  4. 重松明男,豊嶋崇徳:ミニ移植における移植片対宿主病(GVHD)と移植片対白血病(GVL)効果. 血液フロンティア 22(10): 23-30, 2012.
  5. 田中淳司:Ph陰性ALLにおける微小残存病変の検出法とその意義.
    血液内科65:670-674, 2012.
  6. 豊嶋崇徳:GVHDのメカニズムとその克服に向けた細胞療法の展開.
    医学のあゆみ 240 (5): 460-464, 2012.
  7. 豊嶋崇徳: Wntシグナルを標的とした腸管GVHDの制御.
    血液内科 64 (2): 197-201, 2012.
  8. 豊嶋崇徳:移植片対宿主病(GVHD)のマネジメント. がん看護 17 (3): 354-356, 2012.
  9. 豊嶋崇徳:GVHDの成因と治療. 日本臨床 70 (2): 264-268, 2012.
  10. 橋野 聡:ITP治療におけるHelicobacter pylori除菌について.
    Club UBIT October, 8-9, 2012.
  11. 平安山知子, 豊嶋崇徳:献血者不足とPatient Blood Management.
    医学のあゆみ 243 (4): 311-315, 2012.

和文症例報告

  1. 橋野 聡、武藏 学、川村詔導 慢性骨髄性白血病の好塩基球性急性転化
    血液フロンティア 22:749-752, 2012
  2. 安本篤史, 遠藤知之:頭蓋内に偽腫瘍が発生した血友病Aの一例.
    血液フロンティア 22(9): 33-36, 2012.
  3. 早瀬英子,黒澤光俊,米積昌克,鈴木左知子:完全奏効後,早期に中枢神経系に再発した膣原発リンパ腫. 臨床血液53:229-234, 2012.

和文原著

  1. 高畑むつみ,橋野聡,藤本勝也,遠藤知之,小林直樹,黒澤光俊,岩崎博,三宅高義,幸田久平,前川勲,笹川裕,堤豊,宮城島拓人,田中淳司,今村雅寛,豊嶋崇徳:特発性血小板減少性紫斑病治療におけるセファランチン大量療法の有用性 ~後方視的多施設共同研究~.臨床血液 53(12): 1983-90, 2012
  2. 豊嶋崇徳: 免疫学.日本輸血・細胞治療学会認定医制度審議会カリキュラム委員会編:日本輸血・細胞治療学会 認定医制度指定カリキュラム.日本輸血・細胞治療学会.
    pp.38-46, 東京,2012.(分担執筆)
  3. 豊嶋崇徳: GVHDの発症機序.神田善伸編:造血幹細胞移植の基礎と臨床 (改訂版).
    医薬ジャーナル社.pp.77-82, 東京,2012.
  4. 豊嶋崇徳: 急性白血病の造血幹細胞移植療法.大野竜三編:新しい診断と治療のABC
    36/血液4 急性白血病.最新医学社.pp.163-172,東京,2012.
  5. 豊嶋崇徳: 造血幹細胞移植.日本臨床腫瘍学会編:新臨床腫瘍学 改訂第3版.
    南江堂.pp.210-214, 東京,2012.(分担執筆)
  6. 橋野 聡:CASE 28 めまいで近医受診時に偶然血小板減少を指摘された42歳女性.
    嘉数直樹・岡本真一郎編:New専門医を目指すケース・メソッド・アプローチ 血液疾患 第2版.日本医事新報社,pp.288-298,東京,2012.
  7. 政氏伸夫, 田中淳司, 笠井正晴, 小笠原正浩, 小林直樹, 木山善雄, 福井彩佳, 藤本奈緒, 山田実早希, 三輪佳子, 小林正伸,今村雅寛:PBSC採取量予測における末梢血CD34陽性細胞上の接着分子発現の評価方法の検討. Cytometry Research 22:27-31, 2012.

和文著書

  1. 今村雅寛:造血幹細胞移植(適応と方法).今日の治療指針 総編集:山口 徹,北原光夫
    福井次夫,医学書院(東京),562-564,2012
  2. 庄野雄介、今村雅寛、上羽悟史、松島網治:骨髄GVHDによる造血ニッチ障害.Annual Review 血液2012.高久史麿、小澤敬也、坂田洋一、金倉 譲、小島勢 二編集、中外医
    学社(東京)、31-40